Which medication is known to affect urine color significantly?

Rifampin is recognized for its ability to substantially alter the color of urine. This medication is an antibiotic primarily used to treat tuberculosis and other bacterial infections. When rifampin is metabolized in the body, it can cause urine to turn a reddish-orange hue. This change is due to the compound's chemical structure and how it is excreted. Such a color change is usually harmless and is a known side effect that healthcare practitioners often inform patients about to prevent unnecessary concern over the altered appearance of their urine.

In the case of the other medications listed, they do not have the same level of impact on urine color. Amoxicillin may cause some changes in urine but is not known for a significant or distinct color alteration like rifampin. Ranitidine and acetylcysteine also lack a notable effect on urine color, focusing mainly on their respective roles in treating conditions like stomach acid issues and as a mucolytic agent. Understanding the specific side effects of medications is crucial, as it helps healthcare professionals provide appropriate patient education.