Which central nervous system side effect is most commonly associated with cimetidine (Tagamet)?

Cimetidine, a histamine H2-receptor antagonist commonly used to treat conditions like peptic ulcers and gastroesophageal reflux disease, can cross the blood-brain barrier. This ability leads to central nervous system side effects, particularly in certain populations such as the elderly or those with compromised renal function.

Confusion is the most commonly reported CNS side effect associated with cimetidine. It may manifest due to the drug's interaction with neurotransmitter systems in the brain, affecting cognitive function. This makes it particularly important for healthcare providers to monitor patients closely for signs of confusion, especially in vulnerable populations.

While tremors, dizziness, and hallucinations can occur, they are less frequently observed than confusion. This distinction underscores the importance of recognizing confusion as a key side effect of cimetidine usage, facilitating timely intervention and management of patient safety. Understanding these side effects helps promote better patient care and medication management strategies.