When reviewing a client's record before administering nalidixic acid for a urinary tract infection, what should the nurse anticipate regarding warfarin sodium?

The correct answer indicates that the nurse should anticipate a decrease in the warfarin sodium dosage when nalidixic acid is prescribed. This is related to the interaction between nalidixic acid and warfarin. Nalidixic acid is known to potentially increase the anticoagulant effect of warfarin, leading to a higher risk of bleeding. Therefore, in order to maintain therapeutic effectiveness while minimizing the risk of adverse effects such as excessive bleeding, it is prudent to consider a decrease in the warfarin dosage.

It is important for the nurse to monitor the client's coagulation parameters (such as INR) closely following this combination of medications, as adjustments may be necessary based on the client’s response and lab results. Understanding this interplay between medications is crucial in ensuring patient safety and achieving optimal therapeutic outcomes.