When a nurse reviews laboratory results for a client on tacrolimus, what level indicates a potential adverse effect?

Tacrolimus is an immunosuppressive medication used primarily in organ transplant recipients to prevent organ rejection. A critical aspect of monitoring clients on tacrolimus is to watch for potential adverse effects, particularly those associated with its effect on renal function and glucose metabolism.

In this case, a high glucose level can indicate a potential adverse effect of tacrolimus. This medication can cause hyperglycemia as a side effect due to its impact on insulin secretion and glucose tolerance. Clinicians often monitor glucose levels closely in patients receiving tacrolimus to prevent complications such as diabetes or exacerbation of pre-existing diabetes.

Monitoring other lab values mentioned, like potassium levels or white blood cell counts, is also important; however, they may not indicate immediate adverse effects related to tacrolimus in the same way that elevated glucose levels would suggest a metabolic issue potentially linked directly to the medication's use. A normal platelet count does not reflect an adverse effect of tacrolimus; instead, it may show that there is no hematologic toxicity. Thus, high glucose levels stand out as a key indicator of potential complications that warrant further evaluation and intervention in patients treated with tacrolimus.