What is the most concerning side effect for a client taking bupropion hydrochloride (Wellbutrin) after a dosage increase?

Bupropion hydrochloride, commonly known as Wellbutrin, is an antidepressant that can significantly impact the central nervous system. One of the most serious and concerning side effects associated with bupropion, particularly after a dosage increase, is the risk of seizure activity.

This medication can lower the seizure threshold, meaning it makes the brain more susceptible to seizures, especially at higher doses. Therefore, if a client has recently increased their dosage, monitoring for any signs of seizure activity becomes crucial. Factors such as pre-existing seizure disorders, eating disorders, or sudden discontinuation of alcohol or sedatives can further increase the risk of seizures in these patients.

While other side effects like nausea, headache, and dry mouth are concerning and can impact the patient's overall comfort, they do not pose the same immediate and potentially life-threatening risk as seizures. Thus, the potential for seizure activity is prioritized when considering side effects, particularly following a dosage adjustment.