What is a common side effect of pancrelipase that the nurse should monitor?

Pancrelipase is a digestive enzyme replacement therapy commonly prescribed for patients with pancreatic insufficiency, such as those with cystic fibrosis or chronic pancreatitis. A common side effect of pancrelipase therapy is diarrhea. This occurs because the medication helps improve fat digestion, but if the dosage is not appropriately managed, excess fat can result in malabsorption.

Monitoring for diarrhea is particularly important as it can indicate that the dose may need to be adjusted. An excessive amount of undigested fats in the stool can lead to not just diarrhea but also symptoms like abdominal discomfort and nutrient deficiencies if not addressed. This side effect aligns with the function of pancrelipase and the digestive system, making it crucial for the nurse to observe and manage these symptoms in patients receiving this therapy.