Isotretinoin is prescribed for severe acne. What laboratory test is anticipated before administration?

Isotretinoin, a powerful medication used to treat severe acne, has the potential to significantly affect lipid metabolism, which includes increasing triglyceride levels. Therefore, before initiating treatment, it's essential to assess the patient's triglyceride levels to establish a baseline and to avoid potential complications. High triglyceride levels can lead to pancreatitis, a serious condition that can arise if isotretinoin is prescribed without monitoring lipid levels.

Monitoring triglycerides ensures that the healthcare provider can take appropriate actions if levels are elevated, which may involve adjusting the dosage or discontinuing the medication. This precaution is vital for patient safety and effective treatment management.

While other lab tests, such as a complete blood count or white blood cell count, may be important in certain contexts, they are not specifically indicated for assessing the risks associated with isotretinoin. Monitoring platelet count is also not directly related to the specific side effects of isotretinoin. Therefore, evaluating triglyceride levels is the most pertinent laboratory test prior to administering this medication.