In a patient taking zidovudine, what other medication might require monitoring due to interactions?

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Zidovudine (AZT) is an antiretroviral medication primarily used to treat HIV infection. When considering potential interactions, it is important to note that zidovudine can have significant effects on the metabolism and efficacy of other medications, particularly those that are also used in the treatment of HIV.

HIV protease inhibitors are a class of medications that are often used in conjunction with zidovudine to enhance the overall effectiveness of HIV therapy. However, these medications can affect the metabolism of zidovudine, leading to potentially increased levels of zidovudine in the bloodstream. This necessitates careful monitoring of the patient’s health and medication effects, as elevated zidovudine levels can increase the risk of toxicity, primarily related to hematological side effects like anemia and neutropenia.

While antidepressants, opiates, and aspirin can interact with zidovudine, these interactions are generally less significant in terms of clinical management compared to the interactions seen with HIV protease inhibitors. Therefore, the need for close monitoring in patients taking zidovudine who are also prescribed HIV protease inhibitors is critical to ensure safe and effective treatment.

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