For a client with osteoporosis prescribed alendronate (Fosamax), which instruction is most appropriate?

The most appropriate instruction for a client taking alendronate (Fosamax) is to take the medication with a full glass of water after rising in the morning. This is essential for a couple of reasons.

First, alendronate must be taken on an empty stomach to ensure optimal absorption. Food, beverages, and even certain medications can interfere with how the body absorbs alendronate, reducing its effectiveness in treating osteoporosis. Taking it first thing in the morning ensures that the medication is absorbed properly before any food is consumed.

Second, consuming a full glass of water is vital because it helps to dilute the medication and facilitate its passage into the stomach. It is important for clients to remain upright for at least 30 minutes after taking alendronate to prevent esophageal irritation or damage. Therefore, taking the medication with a full glass of water and sitting or standing upright will help minimize these risks.

This instruction aligns with best practices for alendronate administration and improves the likelihood of successful treatment for osteoporosis.