After administering desmopressin acetate, the nurse should monitor for which therapeutic response?

Desmopressin acetate is a synthetic analog of vasopressin (antidiuretic hormone), which primarily works by promoting the reabsorption of water in the kidneys. When desmopressin is administered, its therapeutic response is observed in the form of decreased urinary output, as it helps the body retain water and concentrate the urine. This is particularly relevant in conditions such as diabetes insipidus, where there is excessive urination due to a deficiency of vasopressin.

Monitoring for decreased urinary output is essential, as it indicates that the medication is effectively promoting water retention and reducing the volume of urine produced. If the patient experiences decreased urinary output after administration, this suggests that the desmopressin is functioning as intended.

The other options do not represent expected therapeutic responses to desmopressin. Decreased blood pressure and blood glucose levels are not directly linked to the action of desmopressin, and decreased peripheral edema is more associated with the use of diuretics rather than a retention medication like desmopressin. Therefore, decreased urinary output is the correct indicator of the drug's therapeutic efficacy.