A client reports doubling their daily dosage of bupropion hydrochloride (Wellbutrin). What is the primary risk this client faces?

Doubling the daily dosage of bupropion hydrochloride significantly increases the risk of seizure activity, which is a well-documented side effect of this medication. Bupropion is known to lower the seizure threshold, especially at higher doses. This means that the likelihood of experiencing seizures becomes greater as the dose increases beyond the recommended levels.

While insomnia, weight gain, and orthostatic hypotension can also be side effects associated with bupropion, they are not the most severe or immediate risks compared to seizures. The primary concern when a patient increases the dosage of bupropion is the potential for seizures, making it crucial to adhere to prescribed dosing guidelines to mitigate this risk.